The ever energetic Sacha Chua has a nice video chat up with John Wiegley about Emacs. Wiegley, the author of eshell, is one of those users who pretty much lives in Emacs and he has spent a lot of time optimizing his work flow to leverage Emacs. In this chat, he and Chua talk about that work flow and how he uses Emacs. Wiegley also talks about some of the Emacs hacks he's implemented to help with his day to day work. It's an interesting video and worth 40 minutes of your time.
In addition to the video, Chua has a link to Wiegley's Github page where you can find his
init.el and the associated files he uses. Those are also worth studying because he has a lot of good ideas in them.